[For himself and co-workers in the Michigan State College Group Research on Dental Caries: H. R. HUNT, P. A. WEBBER, and T. L. CANNIFF.]
Caries may be produced, in rats, by inclusion of coarsely ground corn or rice in the diet, regardless of nutritive adequacy. Impaction of particles of corn or rice, and ensuing acid fermentation, appear to be responsible for this result. Caries thus initiated, in rats, may be stopped by eliminating all readily fermentable carbohydrates ; or sustained, with diets in which glucose, sucrose or lactose constitute the only fermentable carbohydrate. Increased resistance to caries occurs in offspring of rats that have received liberal amounts of vitamin D during the gestation period, indicating that in rats prenatal nutri‑tion has an important bearing on susceptibility to caries. Hereditary factors affect susceptibility to caries in the rat. Studies in this relation have reached the third generation of resistant strains, and the fourth generation of susceptible strains, the groups showing striking differences in susceptibility.
References: Science, 74, 77, 1931 ; J. Den. Res., 12, 1, 1932.