Vitamin deficiency in guinea pigs on sterilized food (Otto Stiner) caused hemorrhages and necrosis in dental pulp, blackening and softening of enamel (Caries carbonacea), and degenerative histological changes in parts of salivary glands. These conditions, induced by deficiency of the parasympathetic factor in vitamin B, may lower the quantity and quality of saliva and increase susceptibility to caries. [Reported by Rudolf Jeanneret.]
Reference: Schw. Monat. Zahnh., 1930.