Dental development, like growth and sex development, is influenced by the pituitary gland. The physical structure of teeth is affected indirectly by the action of pituitary secretion on metabolism of mineral substances.
In the very young child delayed dentition, crowding, or wide separation of teeth, are noted in pituitary diseases. In the adolescent, showing evidence of lack of pituitary secretion, caries tends to occur at occlusal surfaces of teeth. In older individuals in this condition—between 20 and 30 years—the degenerative changes usually occur at gum margins. The question arises : What part does Nasmyth’s membrane play in occlusal fissures? Do the cells of this membrane, which early in life are enamelob/astic, change to enameloclastic—as in bone, where cells that are normally osteoblastic develop osteoclastic tendencies?
Reference: Den. Items Int., 60, 1036, 1938