Systemic-physiological coordination, controlled through diet, metabolism and heredity, appears to be the significant factor for the prevention of caries.
A group of children (ages 4-16 years), manifesting extensive generalized hypoplasia of enamel, developed no more caries than children having no gross structural enamel defects. No correlation was found between incidence of caries and (a) feeding during infancy (breast vs. bottle feeding, 281 children) ; (b) or salivary pH, (c) or blood-serum levels of calcium, phosphorus, or protein (in health the body maintains a normal serum-level) ; (d) or diseases of infancy or exanthematous diseases of childhood ; (e) or temperaments of children, but this requires further study. There was some (although no striking) indication that parents who are relatively immune to caries tend to transmit this immunity. State of oral hygiene per se is not a definite factor in prevention or causation of caries, but may contribute significantly in association with other conditions. Amount of carbohydrate in the food is not important, provided all essentials are included in the diet. Addition of viosterol, and use of ultraviolet radiation over the body surface, when diet is deficient, are aids in control of caries. A well balanced diet plays a definite role in control of caries. The number of gram-positive acidogenic bacilli is greatest in mouths manifesting marked caries, but they also occur in caries-free mouths.
The foregoing findings were obtained with children who were grouped and studied for a 3-year period. Each child received full-mouth radiographic examinations at regular intervals. The clinical oral examinations were checked by two dentists, and the results compared with the radiographs. After approximately two years of study, the groups were reversed. The results of the subsequent year of study were almost identical with the previous findings, indicating corroboration.
References: Am. J. Dis. Child., 1933; J. Am. Den. Assoc., 1933; Nutr. Den. Health, 1935.