In man the quality of tooth structure may be adversely affected, during the period of tooth formation, by deficiency of vitamin A. Less striking changes may be produced by deficiency of vitamin C. In guinea-pigs caries does not appear to be associated with defective tooth structure, nor with complete or partial dietary deficiency of either vitamin A or vitamin C.
References: J. Den. Res., 1933, 1934, 1938; Am. J. Path., 1938.